1. Ketamine was first synthesized in 1962 by American chemist, Calvin Stevens.

2. The first human trials of ketamine as an anaesthetic was conducted on August 3, 1964 by Dr. Edward Domino of Pharmacology and Dr. Guenter Corssen of Anaesthesiology, professors at the University of Michigan. 

3. Ketamine is considered to be safer than most other anaesthetic agents since it does not lower blood pressure or depress breathing. 

4. Studies have found that a single dose of ketamine has rapid on depressive symptoms that persists for up to week after dose.

5. Ketamine was the most common battlefield anaesthetic used during the Vietnam War.

 

 

References:

Li, L., & Vlisides, P. E. (2016). Ketamine: 50 Years of Modulating the Mind. Frontiers in human neuroscience10, 612. https://doi.org/10.3389/fnhum.2016.00612

Fact file on ketamine. World Health Organization.  https://www.who.int/medicines/news/20160309_FactFile_Ketamine.pdf

Mandal, S., Sinha, V. K., & Goyal, N. (2019). Efficacy of ketamine therapy in the treatment of depression. Indian journal of psychiatry61(5), 480–485. https://doi.org/10.4103/psychiatry.IndianJPsychiatry_484_18