Magic mushrooms contain a substance called psilocybin. Psilocybin is a tryptamine (a group of organic molecules found in plants, animals, and fungi) that affects the body’s central nervous system. Before psilocybin can be utilized it must be metabolized into psilocin, at which point it affects the neurotransmitter called serotonin. Serotonin is the “happy chemical” that affects our mood and is what causes the euphoria we get from consuming magic mushrooms. Psilocybin and other tryptamines target a specific serotonin receptor called 5-HT2A and, once it does, the “trip’ begins!  

During a “trip” or psychedelic experience people report reality becoming distorted or altered. This altered sense of reality can include hallucinations that involve colors that show up more vibrantly, sounds resonating throughout the body, and time slowing down/speeding up. Vision is also affected, people can experience shapes running together or morphing into something else. Some individuals also experience synesthesia or a blending of senses ex: “Wonder how (does) that color taste?”¹  

Psilocybin also has an influence on the amygdala, the part of our brain that controls emotions including anxiety, fear, and euphoria. Science sees this association as the reason to look into psilocybin for the treatment of PTSD, depression, mood disorders and other psychological disorders. This is also why some people report experiencing a “bad trip” as multiple hallucinogenic variables combined with psilocybin’s effect on the amygdala result in a negative experience. 

Microdosing is the consumption of minimal amounts of a drug in order to obtain a specific response. This has been the protocol that the medical science community has been testing for the mainstream application of psychedelics. When microdosing is practiced the body’s psilocybin tolerance increases rapidly as well as a cross-tolerance to other tryptamines resulting in a very low likelihood of addiction or abuse. 

The pharmaceutical industry requires medications to not only be safe and non-habit forming but also consistent in their dosing. Psilocybin and psilocin are currently classified as Schedule III drugs (Tylenol c codeine under 90mgs, anabolic steroids, & testosterone) and require a prescription however and are not currently provided by any manufacturer.  

In 2019 Silo Wellness established proof of concept for a metered-dose psilocybin nose spray in Jamaica. On November 3, 2020, Oregon passed ballot measure 109 – allowing for medical professionals to prescribe/provide psilocybin and/or psilocybin based products to their patients as part of their treatment process. Silo Wellness was once again ready for this burgeoning industry! Silo has consistently been ahead of the curve in the psychedelic industry and already has a variety of psychedelic retreats in both Oregon and Jamaica that utilize ketamine and psilocybin.  

Go to to learn more about our January 16, 2021 launch of the world’s first Ketamine retreat – and you could be part of it! 




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¹ Cantrell J. (1992) Brother [Song recorded by Artic Monkeys]. On Sap. Washington, USA: Columbia Records.





¹ “Brother” – Alice in Chains